Nameunc-64
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionIncreases hermaphrodite life span by approximately 70% and increases male life span by 150% (Ailion et al. 1999; Ailion and Thomas 2000; Gems and Riddle 2000).
Gene FunctionSyntaxin homolog that interacts with synaptobrevin (Ogawa et al., 1998; Saifee et al. 1998).
Other PhenotypesMutants are uncoordinated (Brenner, 1974) and exhibit a dauer constitutive phenotype (Ailion et al., 2000).
HomologsS.c. SSO2, SSO1, PEP12, TLG2
S.p. pep12, SPCC825.03c, SPAC825.05c
C.e. syn-2, syn-4, F36F2.4, ZC155.7, syn-3, syn-1, VF39H2L.1
D.m. syx1A, EG, CG1467
R.n. Epim, Stx2, Rn.10951, Rn.29974, Stx4, Stx5
M.m. Stx1a, Mm.30318, Stx1b, Epim, Stx3, Stx7 ...
H.s. STX1A, STX1B, STX3A, EPIM, STX11, STX7 ...
Primary ReferenceAilion, M., Inoue, T., Weaver, C. I., Holdcraft, R. W., and Thomas, J. H. (1999). Neurosecretory control of aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A 96, 7394-7. [Abstract]
Other ReferencesAilion, M., and Thomas, J. H. (2000). Dauer formation induced by high temperatures in Caenorhabditis elegans. Genetics 156, 1047-67. [Abstract]
Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Gems, D., and Riddle, D. L. (2000). Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154, 1597-610. [Abstract]
Ogawa, H., Harada, S., Sassa, T., Yamamoto, H., and Hosono, R. (1998). Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin. J Biol Chem 273, 2192-8. [Abstract]
Saifee, O., Wei, L., and Nonet, M. L. (1998). The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin. Mol Biol Cell 9, 1235-52. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=unc-64;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=176743
KeywordsCaenorhabditis, elegans, worm, neurons, sex-specific