OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRNAi
StrainBristol N2
DescriptionRNAi mutants display an increased life span of around 30-40% (Kawano et al., 2000).
Gene FunctionInsulin ligand predicted to bind DAF-2. Homologue of mammalian insulin/insulin -like growth factor (Kawano et al., 2000)
Other PhenotypesRNAi animals are slow growing but do not display any dauer phenotypes (Kawano et al., 2000).
HomologsC.e. F56F3.6
Primary ReferenceKawano, T., Ito, Y., Ishiguro, M., Takuwa, K., Nakajima, T., and Kimura, Y. (2000). Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans. Biochem Biophys Res Commun 273, 431-6.
Gregoire, F. M., Chomiki, N., Kachinskas, D., and Warden, C. H. (1998). Cloning and developmental regulation of a novel member of the insulin-like gene family in Caenorhabditis elegans, Biochem Biophys Res Commun 249, 385-390. [Abstract]
Other ReferencesNone.
Relevant LinksWormPD:
Keywordsmetabolism, insulin, signaling, Caenorhabditis, elegans, worm