Nameunc-6
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionMutation has no effect on life span (Lakowski and Hekimi, 1998).
Gene FunctionLamina protein required for axon guidance (Desai et al., 1988).
Other PhenotypesMutants are uncoordinated (Brenner, 1974).
HomologsC.e. C54D1.5, epi-1, lam-1, unc-52, F33C8.1, VC5.2 ...
D.m. NetA, NetB, LanB2, LanA, LanB1, wb ...
R.n. Lamb2, Rn.10597, Rn.14558, Agrn, Rn.30003
M.m. Ntn1, Ntn3, Lamc3, Lamc1, Lama5, Lamb2 ...
H.s. NTN1, NTN2, LAMC1, LAMC3, LAMA1, LAMB2 ...
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Other ReferencesBrenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Desai, C., Garriga, G., McIntire, S. L., and Horvitz, H. R. (1988). A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature 336, 638-46. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=unc-6;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=180961
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons