Nameunc-54
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionMutation has no effect on life span (Lakowski and Hekimi, 1998).
Gene FunctionMyosin heavy chain (Harris and Epstein, 1977).
Other PhenotypesMutants are paralyzed (Brenner, 1974).
HomologsS.c. MYO1, MYO2, MYO4, MYO5, MYO3
S.p. myo2, myo3, myo52, myo51, SPBC146.13c
C.e. myo-1, myo-2, myo-3, F58G4.1, nmy-1, nmy-2 ...
D.m. zip, didum, ck, CG6976, Myo61F, Myo31DF...
R.n. Myh6, Myh3, Myh9, Myr6, Rn.8737, Myh1 ...
M.m. Myhca, Myh11, Myo5a, Myo7a, Myo10, Myo15 ...
H.s. MYH7, MYH1, MYH4, MYH8, MYH3, MYH13 ...
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Other ReferencesBrenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Harris, H. E., and Epstein, H. F. (1977). Myosin and paramyosin of Caenorhabditis elegans: biochemical and structural properties of wild-type and mutant proteins. Cell 10, 709-19. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=unc-54;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=259839
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons