Nameunc-49
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionThe unc49(e382) allele has no significant effect on life span. (Lakowski and Hekimi, 1998)
Gene FunctionRequired for GABA inhibitory effect on muscles (McIntire et al., 1993). Predicted to form chloride channel in body-wall (Richmond and Jorgensen, 1999).
Other PhenotypesMutants are uncoordinated (Brenner, 1974).
HomologsC.e. F11H8.2, glc-1, glc-3, avr-14, ZC482.5, F25F8.2 ...
D.m. Rdl, Lcch3, GluCalpha, CG14723, CG8916, CG7411 ...
R.n. Gabrb1, Rn.10038, Rn.10670, Gabrb3, Glra1, Gabrb2 ...
M.m. Gabrb1, Gabrb3, Glra1, Gabrb2, Gabrr2, Gabra3 ...
H.s. GABRB1, GABRB2, GABRB3, GABRR1, GLRA1, GABRP ...
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Other ReferencesBrenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
McIntire, S. L., Jorgensen, E., and Horvitz, H. R. (1993). Genes required for GABA function in Caenorhabditis elegans. Nature 364, 334-7. [Abstract]
Richmond, J. E., and Jorgensen, E. M. (1999). One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction. Nat Neurosci 2, 791-7. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=unc-49
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=176427
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons