Nameunc-4
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionMutation has no signigicant effect on hermaphrodite life span (Lakowski and Hekimi, 1998). Life span of unc-4(e120) males is extended relative to hermaphrodites approximately 2-fold (Gems and Riddle, 2000)
Gene FunctionNeuronal homeodomain transcription factor.
Other PhenotypesMutants are uncoordinated (Brenner, 1973).
HomologsS.c. PHO2, YDR451, YOX1
S.p. Spac32A11.03c
C.e. R.08B4.2, ceh-17, mab-18, ceh-10, vab-3, unc-30 ...
D.m. unc-4, OdsH, Pph13, Rx, al, repo, CG15782 ...
R.n. Chx4, Cart1, Rn.10189, Shox2, Rn.2858, Otx1 ...
M.m. Uncx4.1, Arx, Alx4, Shox2, Pax7, Pax3 ...
H.s. CART1, SHOX2, SHOX, RX, PAX7, ARIX ...
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Gems, D., and Riddle, D. L. (2000). Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154, 1597-610. [Abstract]
Other ReferencesBrenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=unc-4;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=174544
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons, sex-specific