OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionIncreases male life span about 170%. No effect on hermaphrodite life span (Gems and Riddle, 2000).
Gene FunctionVesicular ATPase alpha subunit.
Other PhenotypesMutants are uncoordinated (Brenner, 1974).
HomologsS.c. YPH1, STV1
S.p. Spac16E8.07c
C.e. vha-5, vha-6, vha-7
D.m. BcDNA, CG12602, CG18617, CG7678, CG7679
R.n. Rn.6015
M.m. Atp6n1, Tj6
H.s. ATP6N1, TJ6, TCIRG1
Primary ReferenceGems, D., and Riddle, D. L. (2000). Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154, 1597-610. [Abstract]
Other ReferencesBrenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Relevant LinksWormBase:;class=Locus
KeywordsCaenorhabditis, elegans, worm, sex-specific