Nameunc-31
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionIncreases hermaphrodite life span by approximately 70% and increases male life span by 150% (Ailion et al. 1999; Ailion and Thomas, 2000; Gems and Riddle, 2000).
Gene FunctionUnknown. Homologue of vertebrate CAPS, a calcium binding protein required for exocytosis (Ann et al., 1997).
Other PhenotypesMutants are uncoordinated (Brenner, 1974) and exhibit a dauer constitutive phenotype (Ailion et al., 1999). Mutant worms are lethargic, feed constitutively, are defective in egg-laying, and produce dauer larvae that fail to recover (Avery et al, 1993).
HomologsS.c. SSO2, SSO1, PEP12, TLG2
S.p. pep12, SPCC825.03c, SPAC825.05c
C.e. syn-2, syn-4, F36F2.4, ZC155.7, syn-3, syn-1, VF39H2L.1
D.m. syx1A, EG, CG1467
R.n. Epim, Stx2, Rn.10951, Rn.29974, Stx4, Stx5
M.m. Stx1a, Mm.30318, Stx1b, Epim, Stx3, Stx7 ...
H.s. STX1A, STX1B, STX3A, EPIM, STX11, STX7 ...
Primary ReferenceAilion, M., Inoue, T., Weaver, C. I., Holdcraft, R. W., and Thomas, J. H. (1999). Neurosecretory control of aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A 96, 7394-7. [Abstract]
Other ReferencesAilion, M., and Thomas, J. H. (2000). Dauer formation induced by high temperatures in Caenorhabditis elegans. Genetics 156, 1047-67. [Abstract]
Ann, K., Kowalchyk, J. A., Loyet, K. M., and Martin, T. F. (1997). Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+- activated exocytosis. J Biol Chem 272, 19637-40. [Abstract]
Avery, L., Bargmann, C. I., and Horvitz, H. R. (1993). The Caenorhabditis elegans unc-31 gene affects multiple nervous system- controlled functions. Genetics 134, 455-64. [Abstract]
Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Gems, D., and Riddle, D. L. (2000). Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154, 1597-610. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=unc-64;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=178233
KeywordsCaenorhabditis, elegans, worm, neurons, sex-specific