Nameunc-30
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionMutations in unc-30 have no signigicant effect on life span (Lakowski and Hekimi, 1998).
Gene FunctionNeuronal homeodomain transcription factor.
Other PhenotypesMutants are uncoordinated (Brenner, 1973).
HomologsS.c. PHO2
S.p. Spac32A11.03c
C.e. R08B4.2, unc-4, ceh-17, vab-3, ceh-10, ZK993, ...
D.m. Ptx1, al, CG9876, Pph13, Rx, PHDP ...
R.n. Ptx3, Pitx2, Cart1, Rn.10189, Chx4, Rn.2858 ...
M.m. Pitx2, Pitx1, Pitx3, Alx4, Arx, Arix ...
H.s. PITX1, PITX3, PITX2, PAX7, CART1, ARIX ...
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Other ReferencesBrenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=unc-30
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=178265
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons