Nameunc-29
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionMutation has no effect on life span (Lakowski and Hekimi, 1998). Fails to extend male life span (Gems and Riddle, 2000).
Gene FunctionMember of acetylcholine receptor family.
Other PhenotypesMutants are uncoordinated (Brenner, 1973).
HomologsC.e. lev-1, acr-3, acr-2, unc-38, acr-12, acr-16
D.m. nAcRbeta-64B, nAcRbeta-96A, nAcRalpha-96Ab, nAcRalpha-7E, nAcRalpha-96Aa, CG12414 ...
R.n. Chrnb2, Rn.10996, Rn.9713, Rn.9696, Rn.9695, Rn.9694 ...
M.m. Acrb2, Acra4, Acrb, Acra, Acra7, Acrd ...
H.s. CHRNB2, CHRNA6, CHRNA2, CHRNB4, CHRNA3, CHRNA4 ...
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Other ReferencesBrenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Gems, D., and Riddle, D. L. (2000). Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154, 1597-610. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=unc-29;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=172703
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons