Nameunc-26
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol
DescriptionMutations in unc-26 extend life span by 30-50%. Life span extension is proposed to be similar to caloric restriction (Lakowski and Hekimi, 1998)
Gene FunctionNot cloned.
Other PhenotypesMutants are uncoordinated, slow and have defects in pharyngeal pumping (Brenner, 1974; Avery, 1983).
HomologsN/A
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Other ReferencesAvery, L. (1993). The genetics of feeding in Caenorhabditis elegans. Genetics 133, 897-917. [Abstract]
Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=unc-26
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=178284
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons