Nameunc-25
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionMutations in unc-25 have no significant effect on life span (Lakowski and Hekimi, 1998).
Gene FunctionRequired for GABA expression (McIntire et al., 1993).
Other PhenotypesMutants are defective for foraging, locomotion, and defecation (McIntire et al., 1996). Mutants are uncoordinated (Brenner, 1974).
HomologsC.e. K01C8.3, ZK829.2, C05D2.4, C05D2.3, F12A10.3, C09G9.4 ...
D.m. Gad1, b, CG5618, Ddc, Hdc, amd, CG3686
R.n. Gad1, Gad2, Rn.11321, Ddc, Hdc
M.m. Gad1, Gad2, Ddc, Hdc-c
H.s. GAD1, GAD2, CSAD, DDC, HDC
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Other ReferencesBrenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
McIntire, S. L., Jorgensen, E., and Horvitz, H. R. (1993). Genes required for GABA function in Caenorhabditis elegans. Nature 364, 334-7. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=unc-25
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=176713
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons