Nameunc-24
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionMutations in unc-24 have no significant effect on life span. (Lakowski and Hekimi, 1998). unc-24 (e138) fails to extend male life span (Gems and Riddle, 2000).
Gene FunctionUnknown. Predicted to be a plasma membrane channel.
Other PhenotypesMutant is uncoordinated and displays irregular movement (Brenner, 1973; Barnes et al., 1996).
HomologsS.c. None
S.p. Spbc16g5.07c
C.e. sto-4, sto-5, Y71H9A.2, sto-1, sto-2, unc-1, sto-3, mec-2, F30A10.5
D.m. CG7633, CG7468, CG7635, CG17424, CG2970, CG14763, CG14644
R.n. RN.2082
M.m. EPB7.2
H.s. SLP-1, EPB72, SRN1, SLP-2, SCP2
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Other ReferencesBarnes, T. M., Jin, Y., Horvitz, H. R., Ruvkun, G., and Hekimi, S. (1996). The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. J Neuroc [Abstract]
Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Gems, D., and Riddle, D. L. (2000). Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154, 1597-610. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=unc-24
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=177594
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons