Nameunc-2
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionMutation has no effect on life span (Lakowski and Hekimi, 1998).
Gene FunctionSubunit of voltage-gated calcium channel.
Other PhenotypesMutant is uncoordinated (Brenner, 1972). Rate of pharyngeal pumping is reduced (Avery, 1993).
HomologsS.c. CCH1
S.p. Spac6F6.01
C.e. egl-19, C27F2.2, cca-1, C27F2.3, C11D2.6, Y73B6BL.j ...
D.m. nbA, Ca-alpha1D, para, CG4222, CG1517, NaCP60E ...
R.n. Cacna1a, Rn.30066, Rn.10742, Rn.37407, Rn.9827, Cacna1d ...
M.m. Cacna1a, Cacna1b, Cacna1e, Cacna1s, Cacna1f, Mm.30299 ...
H.s. CACNA1B, CACNA1A, CACNA1E, CACNA1F, CACNA1D, CACNA1C ...
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Other ReferencesAvery, L., Bargmann, C. I., and Horvitz, H. R. (1993). The Caenorhabditis elegans unc-31 gene affects multiple nervous system- controlled functions. Genetics 134, 455-64. [Abstract]
Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=unc-2;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=180570
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons