Nameunc-15
OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionMutation has no effect on life span (Lakowski and Hekimi, 1998)
Gene FunctionParamyosin. Muscle filament component.
Other PhenotypesSome alleles show severe paralysis (Brenner, 1974; Gengyo-Ando and Kagawa, 1991).
HomologsC.e. ifa-1, lin-5, Y59A8A.3, klp-12, krp-85, Y45G5AM.B ...
D.m. shot
Primary ReferenceLakowski, B., and Hekimi, S. (1998). The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95, 13091-6. [Abstract]
Other ReferencesBrenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Gengyo-Ando, K., and H. Kagawa, 1991 Single charge change on the helical surface of the paramyosin rod dramatically disrupts thick filament assembly in Caenorhabditis elegans. J Mol Biol 219: 429-441.
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=unc-15;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=172491
KeywordsCaenorhabditis, elegans, worm, caloric restriction, neurons