Nameunc-13
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
Strain
DescriptionMutation increases male life span approximately 150%. No effect on hermaphrodite life span (Gems and Riddle, 2000)
Gene FunctionInvolved in synaptic transmission (Richmond et al., 1999).
Other PhenotypesMutants are uncoordinated (Brenner, 1974).
HomologsS.c. RSP5, YNL087W, YOR086C
S.p. Spbc12C2.05c, pub1, SpapYUK71.033c, Spcp31B10.06
C.e. kin-11, F25B3.3, tpa-1, D2092.1, kin-13, T12A2 ...
D.m. unc-13, inaC, CG6622, Pkc53E, CG8608, CG15078 ...
R.n. Rn.10126, Rn.10127, Rn.11278, Prkcg, Prkcb1, Rasgrp ...
M.m. Unc13h1, Pkcc, Pkca, Pkcb, Rasgrp1, Pkcd ...
H.s. UNC13, PRKCG, PRKCA, PRKCB1, RASGRP1, PRKCD...
Primary ReferenceGems, D., and Riddle, D. L. (2000). Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 154, 1597-610. [Abstract]
Other ReferencesBrenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94. [Abstract]
Richmond, J. E., Davis, W. S., and Jorgensen, E. M. (1999). UNC-13 is required for synaptic vesicle fusion in C. elegans. Nat Neurosci 2, 959-64. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=unc-13;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=172497
KeywordsCaenorhabditis, elegans, worm, neurons