OrganismMus musculus
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionMice that are homozygous for disruption of top3b have a life span that is reduced by approximately 70%.
Gene FunctionType I topoisomerase.
Other PhenotypesYeast Top3p physically interacts with Sgs1p (Gangloff et al., 1994). Human top3a interacts with BLM (Wu et al., 2000; Johnson et al., 2000) and both top3a and top3b interact with RECQ5 (Shimamoto et al., 2000).
HomologsS.c. TOP3
S.p. Top3
C.e. Y48C3A.14, TOP-3
H.s. TOP3
Primary ReferenceKwan, K. Y., and Wang, J. C. (2001). Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan. Proc Natl Acad Sci U S A 1, 1. [Abstract]
Other ReferencesGangloff, S., McDonald, J. P., Bendixen, C., Arthur, L., and Rothstein, R. (1994). The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol Cell Biol 14, 8391-8. [Abstract]
Johnson, F. B., Lombard, D. B., Neff, N. F., Mastrangelo, M. A., Dewolf, W., Ellis, N. A., Marciniak, R. A., Yin, Y., Jaenisch, R., and Guarente, L. (2000). Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells [Abstract]
Shimamoto, A., Nishikawa, K., Kitao, S., and Furuichi, Y. (2000). Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. Nucleic Acids Res 28, 1647-55. [Abstract]
Wu, L., Davies, S. L., North, P. S., Goulaouic, H., Riou, J. F., Turley, H., Gatter, K. C., and Hickson, I. D. (2000). The Bloom's syndrome gene product interacts with topoisomerase III. J Biol Chem 275, 9636-44. [Abstract]
Relevant LinksLocusLink:
KeywordsMus, musculus, mouse