OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionThe cdc25-10 allele extends life-span by about 50% at 30C. CDC25 appears to be in the same genetic pathway for longevity as SIR2 and NPT1 and has been suggested as a genetic model for caloric restriction (Lin et al., 2000).
Gene FunctionGDP-GTP exchange factor for Ras1p and Ras2p (Lin et al., 2000).
Other PhenotypesNull mutant is inviable (Robinson et al., 1987).
HomologsS.c. SDC25, LTE1, BUD5
S.p. efc25, ste6, imp2
C.e. Y34B4A_3.D, SOS-1
D.m. SOS, C3G, CG5522
H.s. GRF2, SOS1
Primary ReferenceLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Other ReferencesRobinson, L. C., Gibbs, J. B., Marshall, M. S., Sigal, I. S., and Tatchell, K. (1987). CDC25: a component of the RAS-adenylate cyclase pathway in Saccharomyces cerevisiae. Science 235, 1218-21. [Abstract]
Relevant LinksSGD:
Keywordscaloric restriction, metabolism, signaling, cell cycle, replicative senescence, Saccharomyces, cerevisiae, yeast