OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeOverexpression
DescriptionOverexpression of a truncated allele of TLC1 abrogates telomere silencing (Singer and Gottschling, 1994) and extends life span (Austriaco and Guarente, 1997). The mechanism of action is likely due to relocalization of SIR2 to the rDNA from the telomeres. SIR2 dosage at the rDNA is a critical determinant of longevity in yeast (Kaeberlein et al., 1999).
Gene FunctionRNA template component of telomerase (Singer and Gottschling, 1994).
Other PhenotypesTLC1 overexpression reduces telomeric silencing (Singer and Gottschling, 1994).
Primary ReferenceAustriaco, N. R., and Guarente, L. P. (1997). Changes of telomere length cause reciprocal changes in the life span of mother cells in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94, 9768-72. [Abstract]
Other ReferencesSinger, M. S., and Gottschling, D. E. (1994). TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 266, 404-9. [Abstract]
Kaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570-80. [Abstract]
Relevant LinksSGD:
Keywordstelomeres, silencing, rDNA, yeast, replicative senescence, Saccharomyces, cerevisiae, RNA