Nametkr-1
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainBristol N2
DescriptionOverexpression increases life span 40-100% (Murakimi and Johnson 1998).
Gene FunctionTyrosine kinase receptor (Murakimi and Johnson 1998)
Other PhenotypesOverexpression causes increased resistance to heat and UV irradiation but does not affect fertility or development (Murakimi and Johnson 1998). Transcription of old-1 is increased in age-1 and daf-2 mutants (Murakimi and Johnson, 2001). old-1 is transcriptionally regulated by daf-16.
HomologsH.s. Fgfr1, Flt1, Csf1r, Mst1r,, Flt4, Epha3 ...
M.m. Fgfr3, Fgfr2, Fgfr1, Fgfr4, Ron, Epha3, ...
R.n. Fgfr2, Rn.9797, Flt1, Rn.24569, Rn.10713, Rn.10617 ...
D.m. htl, btl, CG1061, Ret, Shark, CG18247, ...
C.e. ZK938.5; kin-16; F59F3.5; kin-15, W04G5.6A, Cehd-5 ...
S.p. shk2, cdc7, sex1, pck2, byr2, SPAC2c4.14c ...
S.c. CHK1, CMK2, CLA4, STE11, BCK1, STE20 ...
Primary ReferenceMurakami, S., and Johnson, T. E. (1998). Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene. Curr Biol 8, 1091-4. [Abstract]
Other ReferencesNone.
Murakami, S., and Johnson, T. E. (2001). The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans. Curr Biol 11, 1517-23. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=old-1;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=192055
KeywordsCaenorhabditis, elegans, worm, signaling, dauer, oxidative stress