InterventionTelomere length
Alternate Name
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeN/A
Allele TypeN/A
DescriptionTelomere length correlates inversely with life span in yeast (Austriaco and Guarente, 1997). This is likely due to the relative distribution of SIR2 between the rDNA and telomeres. SIR2 dosage at the rDNA is a critical determinant of longevity in yeast (Kaeberlein et al., 1999). Longer telomeres probably result in less SIR2 at the rDNA and a shorter life span.
Gene FunctionN/A
Other PhenotypesN/A
Primary ReferenceAustriaco, N. R., and Guarente, L. P. (1997). Changes of telomere length cause reciprocal changes in the life span of mother cells in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94, 9768-72. [Abstract]
Other ReferencesKaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570-80. [Abstract]
Relevant LinksNone.
Keywordssilencing, telomeres, rDNA, yeast, replicative senescence, Saccharomyces, cerevisiae