Nametax-4
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionRecessive, loss of function allele can increase life span up to 100%. Life span extension is suppressed by daf-16 and gonad ablation (Apfeld and Kenyon, 1999).
Gene FunctionForms heteromeric cyclic nucleotide-gated channel along with Tax-2 (Coburn et al., 1998).
Other PhenotypesMutants are thermotaxis and chemotaxis defective (Komatsu et al., 1996; Bargmann et al., 1993). Mutants are slightly dauer constitutive and form dauers at 27C (Coburn et al., 1998).
HomologsH.s. Cnga1, Cnga3, Cngb3, Cngb1, Hcn4, Kcnh2 ...
M.m. Cnga3, Cncg, Cncg4, Cng6, Hcn2, Hcn4 ...
R.n. RN.10645, Cncg4, Rn.10886, Rn.10054, Rn.10733, Rn.10970 ...
D.m. Cng, CG3536, CG9176, CG17922, Ih, elk ...
C.e. F14H8.6, Y76B12C.1, C23H5.7, tax-2, wrt-3, unc-103, ...
S.p. cgs1
S.c. BCY1
Primary ReferenceApfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other ReferencesBargmann, C. I., Hartwieg, E., and Horvitz, H. R. (1993). Odorant-selective genes and neurons mediate olfaction in C. elegans. Cell 74, 515-27. [Abstract]
Coburn, C. M., Mori, I., Ohshima, Y., and Bargmann, C. I. (1998). A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure. Development 125, [Abstract]
Komatsu, H., Mori, I., Rhee, J. S., Akaike, N., and Ohshima, Y. (1996). Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans. Neuron 17, 707-18. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=tax-4;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=176297
KeywordsCaenorhabditis, elegans, worm, neurons, dauer