OrganismCaenorhabditis elegans
Aging PhenotypeNo effect on life-span
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function mutation has no effect on life span (Apfeld and Kenyon, 1999).
Gene FunctionSubunit of heteromeric cyclic nucleotide-gated channel. Required for chemotaxis, chemosensation, thermosensation, and outgrowth of neurons.
Other PhenotypesMutants are defective in chemotaxis, thermotaxis, odorant defective and have some dye-filling defects (Coburn and Bargmann, 1996). Mutants show some defects in dauer formation (Komatsu et al., 1999).
HomologsH.s. CNGB3; CNGB1; CNGA1; CNGA3, HCN4, KCNH4...
M.m. Cng6; Cncg4; Cnga3; Cncg, Hcn4, Hcn1...
R.n. Rn.10733; Cncg4; Rn.10654, Rn.10886, Rn.10054, Hcn4
D.m. CG17922; Cng; CG3536, CG9176, Ih, sei, ...
C.e. TAX-4; F14H8.6; Y76B12C.1;C23H5.7, egl-2, wrt-3 ...
S.p. cgs1
Primary ReferenceApfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other ReferencesCoburn, C. M., and Bargmann, C. I. (1996). A putative cyclic nucleotide-gated channel is required for sensory development and function in C. elegans. Neuron 17, 695-706. [Abstract]
Komatsu, H., Jin, Y. H., L'Etoile, N., Mori, I., Bargmann, C. I., Akaike, N., and Ohshima, Y. (1999). Functional reconstitution of a heteromeric cyclic nucleotide-gated channel of Caenorhabditis elegans in cultured cells. Brain Res 821, 160-8. [Abstract]
Relevant LinksWormBase:;class=Locus
KeywordsCaenorhabditis, elegans, worm, neurons, dauer