OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionDisruption shortens mean (87.5% of normal), but not maximum, life span. (Austriaco, 1996a).
Gene FunctionInvolved in cell septation (Camougrand et al., 2000)
Other PhenotypesMutation causes failure of daughter cells to completely detach and results in a multibudded morphology. (Camougrand et al., 2000)
HomologsS.c. SIM1, UTH1, NCA3, YMR244W, TOS1, YJR151C
S.p. psu1, SPBC2G2.17c, SPCC74.07c
C.e. mat-1
R.n. RN.4106
Primary ReferenceAustriaco, N.R. (1996a) “UTH1 and the Genetic Control of Aging in the Yeast, Saccharomyces cerevisiae.” Ph.D. Thesis, Massachusetts Institute of Technology.
Other ReferencesAustriaco, N.R. (1996b) To Bud Until Death: The Genetics of Ageing in the Yeast, Saccharomyces. Yeast 12: 623-630. [Abstract]
Camougrand, N. M., Mouassite, M., Velours, G. M., and Guerin, M. G. (2000). The "SUN" family: UTH1, an ageing gene, is also involved in the regulation of mitochondria biogenesis in Saccharomyces cerevisiae. Arch Biochem Biophys 375, 154-60. [Abstract]
Relevant LinksSGD:
Keywordscell cycle, yeast, replicative senescence, Saccharomyces, cerevisiae