NameSTE4
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
StrainBKY1-14c
DescriptionDeletion has no effect on mean or maximum life span (Kennedy et al., 1995).
Gene FunctionG-protein beta-subunit. Involved in signal transduction by pheromones. Required for response to mating pheromone (Bardwell, et al., 1994).
Other PhenotypesMutants are sterile (Hartwell, 1980).
HomologsS.c. YCR072C, PWP2, LST8, TAF90, ASC1, MDV1
S.p. git5, SPCC18.05c, taf72, taf73, cpc2, tup11
C.e. gpb-1, gpb-2, C36B1.5, W07E6.2, KO6A1.5, K04G11.5
D.m. CG10763, Gbeta13F, Gbeta76C, nle, CG3436, CG5451
R.n. Gnb2, Gnb1, Rn.2568, Rn.5827, Tle4, Plrg1
M.m. Gnb5, Gnb2, Gnb3, Gnb4, Gnb1, Apaf1
H.s. GNB3, GNB2, GNB1, TBL1, WDR5, PAF65B
Primary ReferenceKennedy, B. K., Austriaco, N. R., Zhang, J., and Guarente, L. (1995). Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80, 485-96. [Abstract]
Other ReferencesBardwell, L., Cook, J. G., Inouye, C. J., and Thorner, J. (1994). Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae. Dev Biol 166, 363-79. [Abstract]
Hartwell, L. H. (1980). Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone. J Cell Biol 85, 811-22. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=STE4
YPD: http://www.proteome.com/databases/YPD/reports/STE4.html
Keywordssterility, yeast, replicative senescence, Saccharomyces, cerevisiae, signaling