NameSTE12
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
StrainPSY142, BKY1-14c
DescriptionDeletion has no effect on life span in strain PSY142 or BKY1-14c (Kennedy et al., 1995).
Gene FunctionTranscription factor that binds the pheromone response element (PRE) and activates transcription of genes required for mating (Bardwell et al., 1994). Also functions with Tec1p to induce pseudohyphal growth (Gavrias et al., 1996).
Other PhenotypesNull mutant is sterile (Hartwell, 1980).
HomologsNone
Primary ReferenceKennedy, B. K., Austriaco, N. R., Zhang, J., and Guarente, L. (1995). Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80, 485-96. [Abstract]
Other ReferencesBardwell, L., Cook, J. G., Inouye, C. J., and Thorner, J. (1994). Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae. Dev Biol 166, 363-79. [Abstract]
Gavrias, V., Andrianopoulos, A., Gimeno, C. J., and Timberlake, W. E. (1996). Saccharomyces cerevisiae TEC1 is required for pseudohyphal growth. Mol Microbiol 19, 1255-63. [Abstract]
Hartwell, L. H. (1980). Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone. J Cell Biol 85, 811-22. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=STE12
YPD: http://www.proteome.com/databases/YPD/reports/STE12.html
Keywordsyeast, replicative senescence, Saccharomyces, cerevisiae, sterility, transcription factor