Namespe-26
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function extends life span (Murakami and Johnson, 1996).
Gene FunctionKelch family (actin binding) protein. Required for normal spermatogenesis (Varkey et al., 1995)
Other PhenotypesMutants show reduced fertility (Varkey et al., 1995) and increased resistance to UV radiation and temperature (Murakami and Johnson, 1996).
HomologsC.e. F47D12.7, T16H12.6, R09A8.3, T27E9.4, kel-1, R12E2.1...
D.m. F47D12.7, DBO, CG17925, CG17754, CG3962, CG3571...
M.m BAA34639.1, CAA41413.1, AAB64206.1
H.s. AB026190, KLHL2, LOC51088, FLJ10262, IPP, KLHL3, ...
Primary ReferenceMurakami, S., and Johnson, T. E. (1996). A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 143, 1207-18. [Abstract]
Other ReferencesVarkey, J. P., Muhlrad, P. J., Minniti, A. N., Do, B., and Ward, S. (1995). The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin. Genes Dev 9, 1074-86. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/db/gene/locus?name=spe-26;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=177929
KeywordsCaenorhabditis, elegans, worm, DNA damage