OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionMutation of spe-10 results in a 20% increase in mean life span on solid media (Cypser and Johnson, 1999).
Gene FunctionNot cloned.
Other PhenotypesMutants have a temperature sensitive defect in sperm development (Shakes and Ward, 1989). Life span correlates with thermotolerance and UV resistance (Cypser and Johnson, 1999).
Primary ReferenceCypser, J. R., and Johnson, T. E. (1999). The spe-10 mutant has longer life and increased stress resistance. Neurobiol Aging 20, 503-12. [Abstract]
Other ReferencesShakes, D. C., and Ward, S. (1989). Mutations that disrupt the morphogenesis and localization of a sperm- specific organelle in Caenorhabditis elegans. Dev Biol 134, 307-16. [Abstract]
Relevant LinksWormBase:;class=Locus
KeywordsCaenorhabditis, elegans, worm, sterile