NameSOD2
OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainEG103
DescriptionDeletion of SOD2 decreases survival in stationary phase (Longo et al., 1996) and prevents increased survival conferred by mutation of SCH9 or CYR1 (Fabrizio et al., 2003).
Overexpression of SOD2 in combination with overexpression of SOD1 increases stationary phase survival by 30% (Fabrizio et al., 2003).
Gene FunctionSOD2 codes for manganese superoxide dismutase of the mitochondrial matrix (Longo et al., 1999). This enzyme accounts for 1 to 10% of total cellular SOD activity, depending on culture conditions (Longo et al., 1996). The predominant source of SOD activity is Sod1p, a cytoplasmic Cu,Zn oxidoreductase (Longo et al., 1996).
Other Phenotypessod2 deletion mutants are hypersensitive to oxygen and grow poorly in ethanol (Longo et al., 1999).
HomologsS.p. Spac1486.01, Spbc3h7.04
C.e. sod-2, sod-3
D.m. sod2
R.n. Sod2
M.m. Sod2
H.s. SOD2
Primary ReferenceLongo, V. D., Gralla, E. B., and Valentine, J. S. (1996). Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J Biol Chem 271, 12275-80. [Abstract]
Other ReferencesLongo, V. D., Liou, L. L., Valentine, J. S., and Gralla, E. B. (1999). Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys 365, 131-42. [Abstract]
Fabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=sod2
Keywordsyeast, stationary phase survival, Saccharomyces, cerevisiae, oxidative stress, mitochondria