OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeOverexpression
DescriptionOverexpression of SOD1 has no effect on replicative life-span (Kirchman et al., 1999). Deletion of SOD1 shortens replicative life-span (Wawryn et al., 2002).
Gene FunctionCytosolic copper-zinc superoxide dismutase.
Other PhenotypesYeast lacking sod1 show a profound defect in entry into and survival during stationary phase (Longo et al., 1996; Longo et al., 1999). This defect is partially suppressed by expression of human Bcl-2 (Longo et al., 1997). Deletion of sod1 causes sensitivity to hyperoxia as well as methionine and lysine auxotrophies (Longo et al., 1997).
HomologsS.p. sod1
C.e. sod-1, C15F1.7, ZK430.3
D.m. sod, CG9027, CG17753
R.n. Sod1, Sod3
M.m. Sod1, Ccsd, Sod3
H.s. SOD1, CCS, SOD3
Primary ReferenceKirchman, P. A., Kim, S., Lai, C. Y., and Jazwinski, S. M. (1999). Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae, Genetics 152, 179-90. [Abstract]
Other ReferencesLongo, V. D., Gralla, E. B., and Valentine, J. S. (1996). Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J Biol Chem 271, 12275-12280. [Abstract]
Longo, V. D., Ellerby, L. M., Bredesen, D. E., Valentine, J. S., and Gralla, E. B. (1997). Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. J Cell Biol 137, 1581-1588. [Abstract]
Longo, V. D., Liou, L. L., Valentine, J. S., and Gralla, E. B. (1999). Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys 365, 131-42. [Abstract]
Wawryn, J., Swiecilo, A., Bartosz, G., and Bilinski, T. (2002). Effect of superoxide dismutase deficiency on the life span of the yeast Saccharomyces cerevisiae. An oxygen-independent role of Cu,Zn- superoxide dismutase. Biochim Biophys Acta 1570, 199-202 [Abstract]
Relevant LinksSGD:
KeywordsSaccharomyces, cerevisiae, yeast, oxidative stress, stationary phase survival, replicative senescence