NameSOD1
OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainW303-B
DescriptionYeast lacking sod1 show a profound defect in entry into and survival during stationary phase (Longo et al., 1996; Longo et al., 1999). This defect is partially suppressed by expression of human Bcl-2 (Longo et al., 1997).
Gene FunctionCytosolic copper-zinc superoxide dismutase.
Other PhenotypesDeletion of sod1 causes sensitivity to hyperoxia as well as methionine and lysine auxotrophies (Longo et al., 1997).
HomologsS.p. sod1
C.e. sod-1, C15F1.7, ZK430.3
D.m. sod, CG9027, CG17753
R.n. Sod1, Sod3
M.m. Sod1, Ccsd, Sod3
H.s. SOD1, CCS, SOD3
Primary ReferenceLongo, V. D., Gralla, E. B., and Valentine, J. S. (1996). Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J Biol Chem 271, 12275-12280. [Abstract]
Other ReferencesLongo, V. D., Ellerby, L. M., Bredesen, D. E., Valentine, J. S., and Gralla, E. B. (1997). Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. J Cell Biol 137, 1581-1588. [Abstract]
Longo, V. D., Liou, L. L., Valentine, J. S., and Gralla, E. B. (1999). Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys 365, 131-42. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=sod1
YPD: http://www.proteome.com/databases/YPD/reports/SOD1.html
KeywordsSaccharomyces, cerevisiae, yeast, oxidative stress, stationary phase survival, replicative senescence