OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeOverexpression
DescriptionGeneral overexpression causes up to 48% increase in life span (Sun et al., 1999). Targeted transgenic expression of hSOD1 in motorneurons alone causes 40% increase in mean and maximum life span (Parkes et al., 1998).
Gene Functionsod1 encodes a cytosolic Cu,Zn superoxide dismutase that reduces superoxide anion to hydrogen peroxide.
Other PhenotypesTargeted neuronal expression of SOD1 and CAT together abrogates life span extension by expression of SOD1 alone (Parkes et al., 1998).
HomologsS.c. SOD1
S.p. sod1
C.e. sod-1, C15F1.7, ZK430.3
D.m. CG9027, CG17753
R.n. Sod1, Sod3
M.m. Sod1, Ccsd, Sod3
H.s. SOD1, CCS, SOD3
Primary ReferenceSun, J., and Tower, J. (1999). FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol 19, 216-28. [Abstract]
Other ReferencesParkes, T. L., Elia, A. J., Dickinson, D., Hilliker, A. J., Phillips, J. P., and Boulianne, G. L. (1998). Extension of Drosophila life span by overexpression of human SOD1 in motorneurons. Nat Genet 19, 171-4. [Abstract]
Phillips, J. P., Parkes, T. L., and Hilliker, A. J. (2000). Targeted neuronal gene expression and longevity in Drosophila. Exp Gerontol 35, 1157-1164. [Abstract]
Relevant LinksFlyBase:
KeywordsDrosophila, melanogaster, fly, oxidative stress, neurons