OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeOverexpression
DescriptionHigh-copy 2µ expression level results in life span 75% of wild-type (Ashrafi et al., 2000).
Gene FunctionSerine/threonine kinase (Celenza and Carlson, 1986); required to derepress genes under glucose repression control (Celenza and Carlson, 1984)
Other PhenotypesCells overexpressing SNF1 show biomarkers of aging, including progressive sterility, enlargement and fragmentation of the nucleolus, redistribution of Sir3p to the nucleolus, and more rapid accumulation of ERCs (Ashrafi et al., 2000)
HomologsS.c. GIN4, KCC4, KIN4
S.p. Spcc74.03c, Spac23h4.02
C.e. T01C8.1, par2.3, par-1
D.m. snf1A, CG3051, CG8201
M.m. Emk2, Emk, Msk, Melk
Primary ReferenceAshrafi, K., Lin, S. S., Manchester, J. K., and Gordon, J. I. (2000). Sip2p and its partner Snf1p kinase affect aging in S. cerevisiae. Genes Dev 14, 1872-85. [Abstract]
Other ReferencesCelenza, J. L., and Carlson, M. (1984). Cloning and genetic mapping of SNF1, a gene required for expression of glucose-repressible genes in Saccharomyces cerevisiae. Mol Cell Biol 4, 49-53. [Abstract]
Celenza, J. L., and Carlson, M. (1986). A yeast gene that is essential for release from glucose repression encodes a protein kinase. Science 233, 1175-80. [Abstract]
Relevant LinksSGD:
Keywordsmetabolism, kinase, signaling, yeast, replicative senescence, Saccharomyces, cerevisiae