InterventionCaloric restriction
Alternate Name
OrganismDrosophila melanogaster
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionDecreasing the concentration of food by dilution results in up to 35% increase in life span (Clancy et al., 2002). It was previously reported that restricting the amount of food (yeast) available to flies has no positive effect on longevity (Le Bourg and Minois, 1996).
Gene FunctionN/A
Other PhenotypesThe magnitude of life span extension for wild-type flies is dependent on food concentration and is maximized at 0.6 X normal (Clancy et al., 2002). The maximum life-span extension of chico flies (Clancy et al., 2001) subjected to dietary restriction is not greater than the maximum extension of wild-type flies under dietary restriction (Clancy et al., 2002). However, the relative food concentration at which chico flies achieve maximum life-span is higher (~0.8 X normal) than wild-type animals.

Dietary restriction (DR) in Drosophila extends life-span entirely by reducing the short-term risk of death. Two days after the application of DR at any age for the first time, previously fully fed flies are no more likely to die than flies of the same age that have been subjected to long-term DR (Mair et al., 2003).

Primary ReferenceClancy, D. J., Gems, D., Hafen, E., Leevers, S. J., and Partridge, L. (2002). Dietary restriction in long-lived dwarf flies. Science 296, 319. [Abstract]
Other ReferencesLe Bourg, E., and Minois, N. (1996). Failure to confirm increased longevity in Drosophila melanogaster submitted to a food restriction procedure. J Gerontol A Biol Sci Med Sci 51, B280-3. [Abstract]
Nusbaum, T. J., and Rose, M. R. (1999). The effects of nutritional manipulation and laboratory selection on lifespan in Drosophila melanogaster. J Gerontol A Biol Sci Med Sci 54, B192-8. [Abstract]
Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., and Partridge, L. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-6. [Abstract]
Mair, W., P. Goymer, S. D. Pletcher and L. Partridge, 2003 Demography of dietary restriction and death in Drosophila. Science 301: 1731-1733. [Abstract]
Relevant LinksNone.
KeywordsDrosophila, fly, D. melanogaster, caloric restriction, metabolism