Namesir-2.1
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainBristol N2
DescriptionMulti-copy array extends life-span by up to 50% (Tissenbaum and Guarente, 2001).
Gene FunctionHomology to NAD-dependent histone deacetylases from S. cerevisiae and M. musculus (Imai et al., 2000).
Other PhenotypesLife-span extension by multi-copy array acts in the insulin-like signaling pathway: it is suppressed by a mutation in daf-16 and does not synergize with daf-2. Overexpression of sir-2.1 synergizes with the TGF-beta mutations (daf-4 and daf-1) for dauer formation (Tissenbaum and Guarente, 2001).
Overexpression of the yeast homolog, SIR2, extends replicative life-span in Saccharomyces cerevisiae (Kaeberlein et al., 1999).
HomologsS.c. SIR2, HST1, HST2, HST3, HST4
S.p. Spbc16D10.07c, Spcc132.02, hst4
C.e. F46G10.3, F46G10.7, C06A5.3
D.m. SIR2, CG6284, CG3187
M.m. SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6
H.s. SIRT1, SIRT3, SIRT2, SIRT5, SIRT4
R.n. SIRT2
Primary ReferenceTissenbaum, H. A., and Guarente, L. (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230. [Abstract]
Other ReferencesImai, S., Armstrong, C. M., Kaeberlein, M., and Guarente, L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD- dependent histone deacetylase. Nature 403, 795-800. [Abstract]
Kaeberlein, M., McVey, M., and Guarente, L. (1999). The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13, 2570-80. [Abstract]
Relevant LinksWormBasehttp://www.wormbase.org/db/seq/sequence?name=sir-2.1;class=Locus
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=177924
Keywordscaloric restriction, metabolism, Caenorhabditis, elegans, worm, silencing, chromatin, insulin, signaling, dauer