NameSIP2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainS288C
DescriptionDeletion results in life span that is 60% of wild-type (Ashrafi et al., 2000).
Gene FunctionSip1p, Sip2p and Gal83p are proteins of related but distinct function that form alternate complexes with Snf1p, possibly serving as adapters to direct Snf1p activity (Yang et al., 1994)
Other Phenotypessip2delta strains show biomarkers of aging, including progressive sterility, enlargement and fragmentation of the nucleolus, redistribution of Sir3p to the nucleolus, and more rapid accumulation of ERCs (Ashrafi et al., 2000)
Null mutation causes an increase in the intracellular ATP and NAD+ levels in both young cells (generation 0-1) and older cells (generation 4), but the
increase is greater in older cells (Ashrafi et al., 2000)
HomologsS.c. SIP1, GAL83, YHR146
S.p. cc1919.03c
C.e. F55F3.1
D.m. CG8057
H.s. PRKAB1, PRKAB2
Primary ReferenceAshrafi, K., Lin, S. S., Manchester, J. K., and Gordon, J. I. (2000). Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14, 1872-85. [Abstract]
Other ReferencesYang, X., Jiang, R., and Carlson, M. (1994). A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex. Embo J 13, 5878-86. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=sip2
YPD: http://www.proteome.com/databases/YPD/reports/SIP2.html
Keywordsmetabolism, signaling, yeast, replicative senescence, Saccharomyces, cerevisiae, nucleolus, rDNA