NameSIP1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainS288C
DescriptionDeletion results in life span 80% of wild-type, without accompanying aging biomarkers (Ashrafi et al., 2000).
Gene FunctionProtein involved in glucose repression, possible regulator of Snf1p activity.
Other Phenotypesnone
HomologsS.c. GAL83, SIP2
C.e. Y47D3A.15, F55F3.1
D.m. CG8057
Primary ReferenceAshrafi, K., Lin, S. S., Manchester, J. K., and Gordon, J. I. (2000). Sip2p and its partner snf1p kinase affect aging in S. cerevisiae. Genes Dev 14, 1872-85. [Abstract]
Other Referencesnone
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=sip1
YPD: http://www.proteome.com/databases/YPD/reports/SIP1.html
Keywordsyeast, replicative senescence, Saccharomyces, cerevisiae, metabolism