NameSIM1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainBKy1-14c
DescriptionDisruption shortens mean (87.5% of normal), but not maximum, life span without causing any other gross changes in cell cycle parameters or growth characteristics. (Austriaco, 1996a).
Gene FunctionUnknown.
Other PhenotypesCells bearing deletions in CLB1-4 are unable to undergo mitosis and normally arrest in G2. SIM1 disruption in clb1-4 mutant backgrounds will allow a second round of DNA synthesis without mitosis. (Dahmann, 1995) Also, sim1delta uth1delta double mutants exhibit various defects, including binucleate cells, benomyl sensitivity, heat shock sensitivity, inability to store glycogen, sensitivity to starvation and failure of spores to germinate. (Mouassite, 2000)
HomologsS.c. SUN4, NAC3, UTH1, YMR244W, YJR151C, NUP159, PRY3, SED4
S.p. psu1, Spbc2G2.17c, Spcc74.07c, Spac13F5.04c
C.e. ZC178.2, ptp-1
D.m. CG17255
M.m. Son, Muc1
Primary ReferenceAustriaco, N. R., Jr. (1996a). UTH1 and the Genetic Control of Aging in the Yeast, Saccharomyces cerevisiae. In Biology (Cambridge: Massachusetts Institute of Technology).
Other ReferencesAustriaco, N. R., Jr. (1996b). Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces. Yeast 12, 623-30. [Abstract]
Dahmann C, Diffley JF, Nasmyth KA. (1995) S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr Biol. 5(11):1257-69. [Abstract]
Mouassite M, Guerin MG, Camougrand NM. (2000) The SUN family of Saccharomyces cerevisiae: the double knock-out of UTH1 and SIM1 promotes defects in nucleus migration and increased drug sensitivity. FEMS Microbiol Lett 182(1):137-41. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=SIM1
YPD: http://www.proteome.com/databases/YPD/reports/SIM1.html
Keywordscell cycle, yeast, replicative senescence, Saccharomyces, cerevisiae, heat shock