OrganismSaccharomyces cerevisiae (chronological)
Aging PhenotypeLife-span extension
Allele TypeRecessive
DescriptionDisruption of SCH9 extends chronological life span, as measured by stationary phase survival, up to 300% (Fabrizio et al., 2001).
Deletion of SOD2 prevents the increased stationary phase survival caused by mutation of SCH9. (Fabrizio et al., 2003)
Gene FunctionProtein kinase involved in nutrient signalling in a pathway parallel to the cAMP pathway (Thevelein and de Winde, 1999).
Other PhenotypesDeletion of SCH9 also increases restistance to heat shock and oxidative stress (Fabrizio et al., 2001) and increases replcative life-span by 18% (Fabrizio et al., 2004).
HomologsS. c. Ypk2p; Ypk1p; Tpk3p
S. p. Sck1p; Sck2p
C. e. C12D8.10A; W10G6.2; AKT-2
D. m. AKT1; PKC98E; S6KII
R. n. AKT2; AKT; RN.10506
M. m. AKT; AKT2; AKT3
H. s. AKT1; AKT2; PKBG
Primary ReferenceFabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., and Longo, V. D. (2001). Regulation of longevity and stress resistance by Sch9 in yeast. Science 292, 288-90. [Abstract]
Other ReferencesThevelein, J. M., and de Winde, J. H. (1999). Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol Microbiol 33, 904-18. [Abstract]
Fabrizio, P., Liou, L. L., Moy, V. N., Diaspro, A., SelverstoneValentine, J., Gralla, E. B., and Longo, V. D. (2003). SOD2 Functions Downstream of Sch9 to Extend Longevity in Yeast. Genetics 163, 35-46 [Abstract]
Relevant LinksSGD:
Keywordsheat shock, yeast, Saccharomyces cerevisiae, oxidative stress, stationary phase, replicative senescence