|Organism||Saccharomyces cerevisiae (replicative)|
|Aging Phenotype||Life-span extension|
|Description||A null mutation in RTG3 causes a 55% increase in mean life span at 2% glucose, suggesting that expression of genes regulated by Rtg1p-Rtg3p has a negative|
effect on longevity in 2% glucose (Jiang et al., 2000).
A null mutant has 123% increased mean life span at 0.1% glucose relative to a wild-type strain at 2% glucose, indicating that reduced glucose and an rtg3 mutation have an additive effect on life span (Jiang et al., 2000).
|Gene Function||Rtg3p forms a heterodimeric transcription factor with Rtg1p (Jia et al., 1997).|
It is required for induction of the retrograde response, an intracellular signaling pathway of inter-organelle communication that signals the functional
status of mitochondria to the nucleus to regulate the expression of several genes (Rothermel et al., 1997).
|Other Phenotypes||Null mutant cannot grow on acetate medium and requires glutamate or aspartate for growth (Jia et al., 1997).|
C.e. W02C12.3, MAX-1
M.m. TCFEC, MITF, TCFL4
H.s. TFEC , TCFEB, TFE3
|Primary Reference||Jiang, J. C., Jaruga, E., Repnevskaya, M. V., and Jazwinski, S. M. (2000). An intervention resembling caloric restriction prolongs life span and retards aging in yeast, Faseb J 14, 2135-7. [Abstract]|
Kirchman, P. A., Kim, S., Lai, C. Y., and Jazwinski, S. M. (1999). Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae, Genetics 152, 179-90. [Abstract]
|Other References||Jia, Y., Rothermel, B., Thornton, J., and Butow, R. A. (1997). A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol Cell Biol 17, 1110-7. [Abstract]|
Rothermel, B. A., Thornton, J. L., and Butow, R. A. (1997). Rtg3p, a basic helix-loop-helix/leucine zipper protein that functions in mitochondrial-induced changes in gene expression, contains independent activation domains, J Biol Chem 272, 19801-7. [Abstract]
|Relevant Links||YPD: http://www.proteome.com/databases/YPD/reports/RTG3.html|
|Keywords||yeast, replicative senescence, Saccharomyces, cerevisiae, yeast, metabolism, mitochondria, transcription factor, signaling, retrograde response|