OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
DescriptionA null mutation in RTG3 causes a 55% increase in mean life span at 2% glucose, suggesting that expression of genes regulated by Rtg1p-Rtg3p has a negative
effect on longevity in 2% glucose (Jiang et al., 2000).
A null mutant has 123% increased mean life span at 0.1% glucose relative to a wild-type strain at 2% glucose, indicating that reduced glucose and an rtg3 mutation have an additive effect on life span (Jiang et al., 2000).
Gene FunctionRtg3p forms a heterodimeric transcription factor with Rtg1p (Jia et al., 1997).
It is required for induction of the retrograde response, an intracellular signaling pathway of inter-organelle communication that signals the functional
status of mitochondria to the nucleus to regulate the expression of several genes (Rothermel et al., 1997).
Other PhenotypesNull mutant cannot grow on acetate medium and requires glutamate or aspartate for growth (Jia et al., 1997).
HomologsS.p. Spac3f10.12c
C.e. W02C12.3, MAX-1
D.m. CG3350
R.n RN.37514
Primary ReferenceJiang, J. C., Jaruga, E., Repnevskaya, M. V., and Jazwinski, S. M. (2000). An intervention resembling caloric restriction prolongs life span and retards aging in yeast, Faseb J 14, 2135-7. [Abstract]
Kirchman, P. A., Kim, S., Lai, C. Y., and Jazwinski, S. M. (1999). Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae, Genetics 152, 179-90. [Abstract]
Other ReferencesJia, Y., Rothermel, B., Thornton, J., and Butow, R. A. (1997). A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol Cell Biol 17, 1110-7. [Abstract]
Rothermel, B. A., Thornton, J. L., and Butow, R. A. (1997). Rtg3p, a basic helix-loop-helix/leucine zipper protein that functions in mitochondrial-induced changes in gene expression, contains independent activation domains, J Biol Chem 272, 19801-7. [Abstract]
Relevant LinksYPD:
Keywordsyeast, replicative senescence, Saccharomyces, cerevisiae, yeast, metabolism, mitochondria, transcription factor, signaling, retrograde response