InterventionCaloric restriction
Alternate Name
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeN/A
DescriptionWorms were grown in liquid and fed varying dilutions of food. Life span can be altered during any part of the life cycle by a change in either temperature or food concentration (Klass 1977). A second set of expts grew worms monoxenically with E. coli as a food source and the influence of the bacterial growth conditions on the life span was studied. When bacterial growth was restricted by reducing the concentration of bactopeptone, which was supplied as the energy source in nematode growth medium (NGM), the nematode's life span tended to be prolonged without a marked effect on postembryonic development. The effect of bactopeptone on the life span was clearly observed during the postreproductive period (that is, after the egg-laying stage of the wild-type C. elegans) rather than during the larval to young adult stage. Evidence is presented that this alteration of the life span was not brought about by any factor in the bactopeptone but by the concentration of bacteria (Hosono et al. 1989).
Gene FunctionN/A
Other PhenotypesUnder these growth conditions, the parental age and parental life span both have relatively small effects on progeny life span. The nematode accumulates fluorescent pigment resembling lipofuscin, and becomes less sensitive to ultra-violet radiation as it ages (Klass, 1977).
Primary ReferenceKlass, M. R. (1977). Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech Ageing Dev 6, 413-29. [Abstract]
Hosono, R., Nishimoto, S., and Kuno, S. (1989). Alterations of life span in the nematode Caenorhabditis elegans under monoxenic culture conditions. Exp Gerontol 24, 251-64. [Abstract]
Other ReferencesNone
Relevant LinksNone
KeywordsCaloric restriction, dietary restriction, C. elegans, metabolism, dietary restriction, calorie restriction