NameRTG2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainYPK9
DescriptionRTG2 is required for lifespan extension associated with the retrograde response, a pathway that signals the functional status of mitochondria to the nucleus to regulate the expression of several genes (Kirchman et al., 1999). RTG2 is not required for lifespan extension caused by caloric restriction (Jiang et al., 2000).
Gene FunctionRTG2 codes for a transcription factor required for the retrograde response, a pathway that signals the functional status of mitochondria to the nucleus to regulate the expression of several genes (Liao and Butow, 1993).
Other PhenotypesNull mutants of RTG2 are not petite (Liao and Butow, 1993) but display various nutrient auxotrophies and alterations of carbohydrate metabolism (Small et al., 1995).
HomologsNone
Primary ReferenceKirchman, P. A., Kim, S., Lai, C. Y., and Jazwinski, S. M. (1999). Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae, Genetics 152, 179-90. [Abstract]
Other ReferencesJiang, J. C., Jaruga, E., Repnevskaya, M. V., and Jazwinski, S. M. (2000). An intervention resembling caloric restriction prolongs life span and retards aging in yeast, Faseb J 14, 2135-7. [Abstract]
Small, W. C., Brodeur, R. D., Sandor, A., Fedorova, N., Li, G., Butow, R. A., and Srere, P. A. (1995). Enzymatic and metabolic studies on retrograde regulation mutants of yeast. Biochemistry 34, 5569-76. [Abstract]
Liao, X., and Butow, R. A. (1993). RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus, Cell 72, 61-71. [Abstract]
Relevant LinksYPD: http://www.proteome.com/databases/YPD/reports/RTG2.html
SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=RTG2
Keywordsyeast, replicative senescence, Saccharomyces, cerevisiae, metabolism, mitochondria, transcription factor, signaling, retrograde response