OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionDeletion of RIF1 increases telomere length (Hardy et al., 1992) and shortens life span approximately 40% (Austriaco and Guarente, 1997). The mechanism of life span shortening is likely due to recruitment of SIR2 from the rDNA to the telomeres (Austriaco and Guarente, 1997; Kaeberlein et al., 1999). The sir4-42 allele suppresses the short life span of a rif1 mutant (Austriaco and Guarente, 1997).
Gene FunctionUnknown. Interacts with Rap1p (Hardy et al., 1992).
Other PhenotypesDeletion causes increased telomeric silencing and telomere length (Hardy et al., 1992, Kyrion et al., 1993).
HomologsS.p. hrp1, Spbc1711.05
C.e. F41H10
R.n. MYH3
Primary ReferenceAustriaco, N. R., and Guarente, L. P. (1997). Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94, 9768-72. [Abstract]
Other ReferencesHardy, C. F., Sussel, L., and Shore, D. (1992). A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev 6, 801-14. [Abstract]
Kyrion, G., Liu, K., Liu, C., and Lustig, A. J. (1993). RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae. Genes Dev 7, 1146-59. [Abstract]
Relevant LinksYPD:
KeywordsSilencing, telomeres, rDNA, yeast, replicative senescence, Saccharomyces, cerevisiae