NameRAS2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeOverexpression
StrainSP1
DescriptionOverexpression of RAS2 caused a 43% increase in mean and 18% increase in maximum lifespan (Sun, 1994).
Gene FunctionGTP-binding protein involved in regulation of the cAMP pathway.
Other PhenotypesRAS2 deletion caused a 23% decrease in mean and a 30% decrease in maximum lifespan (Sun, 1994).
HomologsS.c. Ras1p, Rsr1p, Ypt1p
S.p. Ras1p, Rhb1p, Ypt1p
C.e .C27B7.8, RAS-2, LET-60
D.m. R, RIC, RAS85D
R.n. RN.10007, RN.11271, HRAS
M.m. KRAS2, NRAS, HRAS1
H.s. TC21, KRAS2, NRAS
Primary ReferenceSun, J., Kale, S. P., Childress, A. M., Pinswasdi, C., and Jazwinski, S. M. (1994). Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269, 18638-45. [Abstract]
Other ReferencesNone.
Relevant LinksYPD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=ras2
SGD: http://www.proteome.com/databases/YPD/reports/RAS2.html
Keywordsyeast, Saccharomyces cerevisiae, cAMP, caloric restriction, metabolism, replicative senescence