NameRAS1
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeDeletion
StrainSP1
DescriptionDeletion results in a 23% increase in mean and 29% increase in maximum lifespan (Sun, 1994).
Gene FunctionGTP-binding protein involved in regulation of the cAMP pathway.
Other PhenotypesOverexpression had no effect on lifespan (Sun, 1994).
HomologsS.c. Ras2p, Rsr1p, Ypt1p
S.p. Ras1p, Rhb1p, Ypt2p
C.e. C27B7.8, RAS-2, LET-60
D.m. R, RIC, RAS85D
R.n. RN.10007, RN.11271, HRAS
M.m. KRAS2, NRAS, RIN, RIT
H.s. TC21, KRAS2, NRAS
Primary ReferenceSun, J., Kale, S. P., Childress, A. M., Pinswasdi, C., and Jazwinski, S. M. (1994). Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 269, 18638-45. [Abstract]
Other ReferencesNone.
Relevant LinksYPD: http://www.proteome.com/databases/YPD/reports/RAS1.html
SGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=ras1
Keywordsyeast, Saccharomyces cerevisiae, cAMP, caloric restriction, metabolism, replicative senescence