NameRAD9
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainDBY747, W303
DescriptionMutation of RAD9 shortens life span by 30% in strain DBY747 (Kennedy et al., 1994) and in strain W303 (McVey et al., 2001).
Gene FunctionRequired for DNA-damage induced arrest in G2 (Weinert and Hartwell, 1988) and G1 (Siede et al., 1993).
Other PhenotypesMutation of RAD9 has no effect on telomeric silencing or length (Longhese et al., 2000).
HomologsS.c. YFR016c, YGR196c, SRP40, ESC1
S.p. rhp9, Spbc1711.05, PI006, Spbc215.13, gar2, Spbc21D10.06c, Spac26F1.09
C.e. Y38B5A.A, C11G6.3, F52C9.8, ZK354.3, T04F3.1
R.n. RN.10733
H.s. ATRX
Primary ReferenceKennedy, B. K., Austriaco, N. R., and Guarente, L. (1994). Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J Cell Biol 127, 1985-93. [Abstract]
Other ReferencesLonghese, M. P., Paciotti, V., Neecke, H., and Lucchini, G. (2000). Checkpoint proteins influence telomeric silencing and length maintenance in budding yeast. Genetics 155, 1577-91. [Abstract]
McVey, M., Kaeberlein, M., Tissenbaum, H. A., and Guarente, L. (2001). The Short Life Span of Saccharomyces cerevisiae sgs1 and srs2 Mutants Is a Composite of Normal Aging Processes and Mitotic Arrest Due to Defective Recombination. Genetics 157, 1531-42. [Abstract]
Siede, W., Friedberg, A. S., and Friedberg, E. C. (1993). RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 90, 7985-9. [Abstract]
Weinert, T. A., and Hartwell, L. H. (1988). The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241, 317-22. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=RAD9
YPD: http://www.proteome.com/databases/YPD/reports/RAD9.html
KeywordsDNA damage, yeast, replicative senescence, Saccharomyces, cerevisiae, cell cycle