OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
DescriptionDeletion has no effect on life span in PSY316 (Park et al., 1999).
Gene FunctionInvolved in nucleotide excision repair of inactive genes (Scott and Waters, 1997).
Other PhenotypesMutation results in decreased repair of the non-transcribed strand in rDNA (Verhage et al., 1996).
HomologsS.c. GRR1
S.p. rad7, Spbc25B2.11
C.e. C02F5.7
D.m. CG9952, CG8272, CG14134, CCG12402
M.m. FBX013
H.s. FBL3
Primary ReferencePark, P. U., Defossez, P. A., and Guarente, L. (1999). Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae. Mol Cell Biol 19, 3848-56. [Abstract]
Other ReferencesScott, A. D., and Waters, R. (1997). Inducible nucleotide excision repair (NER) of UV-induced cyclobutane pyrimidine dimers in the cell cycle of the budding yeast Saccharomyces cerevisiae: evidence that inducible NER is confined to the G1 phase of the mit [Abstract]
Verhage, R. A., Van de Putte, P., and Brouwer, J. (1996). Repair of rDNA in Saccharomyces cerevisiae: RAD4-independent strand- specific nucleotide excision repair of RNA polymerase I transcribed genes. Nucleic Acids Res 24, 1020-5. [Abstract]
Relevant LinksSGD:
Keywordshomologous recombination, rDNA, DNA damage, yeast, replicative senescence, Saccharomyces, cerevisiae