OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionDeletion causes a 40% reduction in mean life span in strain PSY316 (Park et al., 1999).
Gene FunctionInvolved in homologous recombination (Basile et al., 1992). Rad51p promotes strand-exchange between homologous single-stranded and double-stranded DNA (Sung, 1994). Member or RAD52 epistasis group (Sung, 2000).
Other PhenotypesRad51p is required for gene conversion, but not for repair of an HO-induced double-strand break (Malkova et al., 1996). Deletion of rad51 decreases formation of extrachromosomal rDNA circles (Park et al., 1999).
HomologsS.c. DMC1, RAD57,
S.p. rhp51, dmc1, rhp57
C.e. RAD-51
D.m. RAD51, SPN-B, CG2412
M.m. RAD51, DMC1H, RAD51L1, XRCC2, RAD51L3
H.s. RAD51, DMC1, RAD51L1, XRCC3, XRCC2, RAD51L3
Primary ReferencePark, P. U., Defossez, P. A., and Guarente, L. (1999). Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae. Mol Cell Biol 19, 3848-56. [Abstract]
Other ReferencesSung, P., Trujillo, K. M., and Van Komen, S. (2000). Recombination factors of Saccharomyces cerevisiae. Mutat Res 451, 257-75. [Abstract]
Malkova, A., Ivanov, E. L., and Haber, J. E. (1996). Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication. Proc Natl Acad Sci U S A 93, 7131-6. [Abstract]
Sung, P. (1994). Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein. Science 265, 1241-3. [Abstract]
Basile, G., Aker, M., and Mortimer, R. K. (1992). Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51. Mol Cell Biol 12, 3235-46. [Abstract]
Relevant LinksSGD:
KeywordsERC, DNA damage, homologous recombination, yeast, replicative senescence, Saccharomyces, cerevisiae