NameRAD26
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
StrainPSY316
DescriptionDeletion has no effect on life span in PSY316 (Park et al., 1999).
Gene FunctionPredicted by homology to be a helicase. Involved in transcription-coupled repair (Verhage et al., 1996).
Other PhenotypesMutant is defective for transcription-coupled repair but shows no defect in global genome repiar (Verhage et al., 1996).
HomologsS.c. STH1, ISW2, SNF2, CHD1, RAD54, ISW1...
S.p. rhp26, Spac1250.01, rad54, hrp1, hrp3, Spcc830.01c ...
C.e. F53H4.1, C52B9.8, psa-4, T04D1.4, W06D4.6, F37A4.8 ...
D.m. okr, Hel89B, CG18438, brm, Iswi, Chd1 ...
M.m. Chd1, Rad54l, Hells, Etl1, Xnp, Mm.3909, Smarcal1
H.s. ERCC6, RAD54B, SMARCA4, SMARCA2, SMARCA5, SMARCA1 ...
Primary ReferencePark, P. U., Defossez, P. A., and Guarente, L. (1999). Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae. Mol Cell Biol 19, 3848-56. [Abstract]
Other ReferencesVerhage, R. A., van Gool, A. J., de Groot, N., Hoeijmakers, J. H., van de Putte, P., and Brouwer, J. (1996). Double mutants of Saccharomyces cerevisiae with alterations in global genome and transcription-coupled repair. Mol Cell Biol 16, 496-502. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=RAD26
YPD: http://www.proteome.com/databases/YPD/reports/RAD26.html
KeywordsDNA damage, yeast, replicative senescence, Saccharomyces, cerevisiae