InterventionCaloric restriction
Alternate Name
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainPSY316, W303R
DescriptionGrowth of yeast cells on YEP+0.5% glucose extends life-span by approximately 40% relative to cells grown on YEP+2% glucose (Lin et al., 2000). Life-span extension requires SIR2 and NPT1, a gene involved in cellular NAD+ synthesis (Lin et al., 2000). Life-span extension by caloric restriction does not require induction of the retrograde response, a signaling pathway communicating functional status of mitochondria to the nucleus (Jiang et al., 2000).
Gene FunctionN/A
Other PhenotypesCalorically restricted cells undergo respiration as measured by increased oxygen consumption and have a gene expression profile that is significantly similar to cells lacking HXK2 or overexpressing HAP4 (Lin et al., 2002).
Primary ReferenceLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Other ReferencesJiang, J. C., Jaruga, E., Repnevskaya, M. V., and Jazwinski, S. M. (2000). An intervention resembling caloric restriction prolongs life span and retards aging in yeast. Faseb J 14, 2135-7. [Abstract]
Lin, S. J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P. A., Culotta, V. C., Fink, G. R., and Guarente, L. (2002). Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418, 344-8. [Abstract]
Relevant LinksNone
KeywordsCaloric restriction, NAD, retrograde response, replicative senescence, Saccharomyces, cerevisiae, yeast, dietary restriction, calorie restriction