InterventionCaloric restriction
Alternate Name
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainPSY316, W303R
DescriptionGrowth of yeast cells on YEP+0.5% glucose extends life-span by approximately 40% relative to cells grown on YEP+2% glucose (Lin et al., 2000). Life-span extension requires SIR2 and NPT1, a gene involved in cellular NAD+ synthesis (Lin et al., 2000). Life-span extension by caloric restriction does not require induction of the retrograde response, a signaling pathway communicating functional status of mitochondria to the nucleus (Jiang et al., 2000).
Gene FunctionN/A
Other PhenotypesCalorically restricted cells undergo respiration as measured by increased oxygen consumption and have a gene expression profile that is significantly similar to cells lacking HXK2 or overexpressing HAP4 (Lin et al., 2002).
HomologsN/A
Primary ReferenceLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Other ReferencesJiang, J. C., Jaruga, E., Repnevskaya, M. V., and Jazwinski, S. M. (2000). An intervention resembling caloric restriction prolongs life span and retards aging in yeast. Faseb J 14, 2135-7. [Abstract]
Lin, S. J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P. A., Culotta, V. C., Fink, G. R., and Guarente, L. (2002). Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418, 344-8. [Abstract]
Relevant LinksNone
KeywordsCaloric restriction, NAD, retrograde response, replicative senescence, Saccharomyces, cerevisiae, yeast, dietary restriction, calorie restriction